Hi @moses-woolpert ,
Do you have a specific question here? It seems like you have found that we provide program types with pollination that describe data centers, which were taken from the DoE prototype buildings referenced in that PDF.
Assigning those to your Rooms will give them electric equipment loads and schedules that align with those of the data center prototype model.
Is your question about which HVAC system template included in Pollination best fits the description of a “Computer Room Air handling Unit with Central Chiller”? If so, I would probably choose a Variable Air Volume (VAV) system:

… and just make sure that you choose one of the options with “chiller” in the “HVAC Equipment Types”:

If you assign a separate one of these VAV systems for each computer room, you will effectively get an OpenStudio model where each computer room has its own AHU but they are all connected to a central chilled water loop like that PDF describes. And you’ll effectively have something that satisfies practically all of the criteria for the Large Data Center described in this table taken from the PDF:
Granted, none of the template HVAC systems in Pollination have water side economizers in them so, if that’s really important to you, you would have to build your own VAV system in Ironbug. But, as the table notes, water side economizers are a relatively new requirement by the energy code and I think they might not be required in all climate zones. So I would think you could still run some studies without it and have a reasonably accurate model for making decisions about which strategies to implement.

